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Project_06 Q17 StudyTitle Probing the mode of action of quinpirole on behavior: role of the monoamine oxidase inhibitor (MAOI) sensitive quinpirole binding site (MQB)
Federated Research Data Repository / dépôt fédéré de données de recherche
Culver, Kirsten E.; Waxman, Donna; Szechtman, Henry; Dvorkin-Gheva, Anna — This study (Q17) is one of a series of studies performed in the Szechtman lab at McMaster University and deposited in the FRDR public repository as a collection under the name "A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection". This collection as a whole constitutes a big dataset containing raw data objects of video, track, and path plot records of rats exploring for 55 minutes a large testing environment in a standardized paradigm during chronic treatment with psychostimulant drugs; for details of this big dataset see, https://www.frdr-dfdr.ca/repo/collection/szechtmanlab. The historical context for study Q17 was Project_06 entitled: "Probing the mode of action of quinpirole on behavior". Title of experiment in Q17 was "Differential effects of clorgyline (a MAO inhibitor) on sensitization to QNP in rats tested in small and large environments". https://creativecommons.org/licenses/by/4.0/
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Project_01 Q22 StudyTitle Probing the neural circuit mediating sensitization and compulsive checking: role of the infralimbic (IL) cortex on expression
Federated Research Data Repository / dépôt fédéré de données de recherche
Ray, Laura B.; Szechtman, Henry; Dvorkin-Gheva, Anna — This study (Q22) is one of a series of studies performed in the Szechtman lab at McMaster University and deposited in the FRDR public repository as a collection under the name "A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection". This collection as a whole constitutes a big dataset containing raw data objects of video, track, and path plot records of rats exploring for 55 minutes a large testing environment in a standardized paradigm during chronic treatment with psychostimulant drugs; for details of this big dataset see, https://www.frdr-dfdr.ca/repo/collection/szechtmanlab. The historical context for study Q22 was Project_01 entitled: "Probing the neural circuit mediating sensitization and compulsive checking". Title of the experiment in Q22 was "Effect of an NMDA lesion of the infralimbic ctx on expression of compulsive checking". For this expression study, rats received our standard treatment to induce compulsive checking and then received a lesion targeted at the infralimbic cortex (IL) and the effect of this lesion on the expression of compulsive checking was measured. This experiment was run in 3 batches to refine success in lesioning IL. Study Q22 was also part of a second project, Project_09 entitled: "Probing the environmental modulation of sensitization and compulsive checking", where title of the experiment was "Effect of testing under infra-red illumination on the expression of sensitization and compulsive checking". This experiment was an add-on for batch 2 rats where at the end of prescribed testing, rats received two more trials (injections 14 and 15) to compare performance under usual illumination with performance under darkness with no visible light in the testing room. https://creativecommons.org/licenses/by/4.0/
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Project_03 Q36 StudyTitle Pharmacology of sensitization and compulsive checking: dose-response profile of mCPP (0 0.3125 0.625 or 1.25 mg/kg)
Federated Research Data Repository / dépôt fédéré de données de recherche
Tucci, Mark C.; Szechtman, Henry; Dvorkin-Gheva, Anna — This study (Q36) is one of a series of studies performed in the Szechtman lab at McMaster University and deposited in the FRDR public repository as a collection under the name "A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection". This collection as a whole constitutes a big dataset containing raw data objects of video, track, and path plot records of rats exploring for 55 minutes a large testing environment in a standardized paradigm during chronic treatment with psychostimulant drugs; for details of this big dataset see, https://www.frdr-dfdr.ca/repo/collection/szechtmanlab. The historical context for study Q36 was Project_03 entitled: "Pharmacology of sensitization and compulsive checking". Title of experiment in Q36 was "Effect of mCPP dose (0 0.3125 0.625 or 1.25 mg/kg) on the development of sensitization and compulsive checking". https://creativecommons.org/licenses/by/4.0/
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Project_03 Q35 StudyTitle Pharmacology of sensitization and compulsive checking: dose-response profile of 8OHDPAT (0 0.03 0.125 0.25 and 1 mg/kg)
Federated Research Data Repository / dépôt fédéré de données de recherche
Alkhatib, Ahmad Hamdi; Szechtman, Henry; Dvorkin-Gheva, Anna — This study (Q35) is one of a series of studies performed in the Szechtman lab at McMaster University and deposited in the FRDR public repository as a collection under the name "A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection". This collection as a whole constitutes a big dataset containing raw data objects of video, track, and path plot records of rats exploring for 55 minutes a large testing environment in a standardized paradigm during chronic treatment with psychostimulant drugs; for details of this big dataset see, https://www.frdr-dfdr.ca/repo/collection/szechtmanlab. The historical context for study Q35 was Project_03 entitled: "Pharmacology of sensitization and compulsive checking". Title of experiment in Q35 was "Effect of 8OHDPAT dose (0 0.03 0.125 0.25 and 1 mg/kg) on the development of sensitization and compulsive checking". Study Q35 was part also of a second project, Project_04 entitled: "Probing for drugs that mitigate sensitization and compulsive checking" where title of the experiment was "Effect of acute escitalopram on the expression of sensitization and compulsive checking". https://creativecommons.org/licenses/by/4.0/
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Project_04 Q37 StudyTitle Probing for drugs that mitigate sensitization and compulsive checking: effect of mCPP dose (0 0.625 and 1.25 mg/kg) on development produced by a low dose of QNP (0.125 mg/kg)
Federated Research Data Repository / dépôt fédéré de données de recherche
Tucci, Mark C.; Szechtman, Henry; Dvorkin-Gheva, Anna — This study (Q37) is one of a series of studies performed in the Szechtman lab at McMaster University and deposited in the FRDR public repository as a collection under the name "A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection". This collection as a whole constitutes a big dataset containing raw data objects of video, track, and path plot records of rats exploring for 55 minutes a large testing environment in a standardized paradigm during chronic treatment with psychostimulant drugs; for details of this big dataset see, https://www.frdr-dfdr.ca/repo/collection/szechtmanlab. The historical context for study Q37 was Project_04 entitled: "Probing for drugs that mitigate sensitization and compulsive checking". Title of experiment in Q37 was "Effect of mCPP dose (0.625 and 1.25 mg/kg) co-injected with a fixed dose of QNP (0.125 mg/kg) on the development of sensitization and induction of compulsive checking". https://creativecommons.org/licenses/by/4.0/
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Project_11 Q48 StudyTitle Probing for biological markers of the pathogenesis of compulsive checking: mRNA expression and changes in gut microbiota
Federated Research Data Repository / dépôt fédéré de données de recherche
Szechtman, Henry; Dvorkin-Gheva, Anna — This study (Q48) is one of a series of studies performed in the Szechtman lab at McMaster University and deposited in the FRDR public repository as a collection under the name "A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection". This collection as a whole constitutes a big dataset containing RAWDATA objects (video, track, path plot and EthoVision files) of rats exploring for 55 minutes a large testing environment in a standardized paradigm during chronic treatment with psychostimulant drugs; for details of this big dataset see, https://www.frdr-dfdr.ca/repo/collection/szechtmanlab. The historical context for study Q48 was Project_11 entitled: "Probing for biological markers of the pathogenesis of compulsive checking". The particular question investigated in Q48 was whether the developments of compulsive checking and locomotor sensitization were accompanied by changes in gene expression and microbiome composition. Findings of gut microbiota changes during induction of compulsive checking and sensitization to quinpirole had been published (https://doi.org/10.1097/FBP.0000000000000363). Results of mRNA expression were inconclusive and not published; raw data are included in sub-folder 11_SPSS_savMasterFiles. Aside the RAWDAA objects (video, track, path plot, and EthoVision files) provided by every study in the Szechtman Lab Collection, study Q48 deposit contains derived data for measures of compulsive checking and locomotion as well as files that document specifics of the study, as described in the README.txt file. https://creativecommons.org/licenses/by/4.0/
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Project_02 Q46 StudyTitle Probing the neurochemistry of sensitization and compulsive checking: dopamine and serotonin systems
Federated Research Data Repository / dépôt fédéré de données de recherche
Szechtman, Henry; Dvorkin-Gheva, Anna — This study (Q46) is one of a series of studies performed in the Szechtman lab at McMaster University and deposited in the FRDR public repository as a collection under the name "A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection". This collection as a whole constitutes a big dataset containing raw data objects of video, track, and path plot records of rats exploring for 55 minutes a large testing environment in a standardized paradigm during chronic treatment with psychostimulant drugs; for details of this big dataset see, https://www.frdr-dfdr.ca/repo/collection/szechtmanlab. The historical context for study Q46 was Project_02 entitled: "Probing the neurochemistry of sensitization and compulsive checking". Title of experiment in Q46 was "Effect of 8OHDPAT dose (0 0.03125 0.0625 0.125 mg/kg) co-injected with a low dose of QNP (0.125 mg/kg) on the development of sensitization and compulsive checking (batch 2). Q46 is repeated as Study Q47 (hence "batch 1" in title of experiment for Q46). For Q46, each rat received 13 trials in the open field. https://creativecommons.org/licenses/by/4.0/
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Project_01 Q26 StudyTitle Probing the neural circuit mediating sensitization and compulsive checking: role of the nucleus accumbens core (NAc) on development, and, on expression
Federated Research Data Repository / dépôt fédéré de données de recherche
Silva, Charmaine A.; Szechtman, Henry; Dvorkin-Gheva, Anna; Ballester Gonzalez, Javier — This study (Q26) is one of a series of studies performed in the Szechtman lab at McMaster University and deposited in the FRDR public repository as a collection under the name "A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection". This collection as a whole constitutes a big dataset containing raw data objects of video, track, and path plot records of rats exploring for 55 minutes a large testing environment in a standardized paradigm during chronic treatment with psychostimulant drugs; for details of this big dataset see, https://www.frdr-dfdr.ca/repo/collection/szechtmanlab. The historical context for study Q26 was Project_01 entitled: "Probing the neural circuit mediating sensitization and compulsive checking". This project had two separate studies, designated as Q26NAc1 and Q26NAc2. The title of study Q26NAc1 was "Probing the neural circuit mediating sensitization and compulsive checking: role of the nucleus accumbens core (NAc) on development" and the title of study Q26NAc2 was "Probing the neural circuit mediating sensitization and compulsive checking: role of the nucleus accumbens core (NAc) on expression". Study Q26NAc1 had two experiments, the first one with the title "Effect of an NMDA lesion of the NAc on the development of sensitization and compulsive checking (batch 1)" and the second one, which was a repeat of the first experiment, had the title "Effect of an NMDA lesion of the NAc on the development of sensitization and compulsive checking (batch 2)". The title of experiment in Q26NAc2 was "Effect of an NMDA lesion of the NAc on the expression of sensitization and compulsive checking". For the development study (Q26NAc1), rats received a lesion targeted at the NAc and the effect of this lesion on the induction of compulsive checking in our standard paradigm was measured. For the expression study (Q26NAc2), rats received our standard treatment to induce compulsive checking and then received a lesion targeted at the NAc and the effect of this lesion on the expression of compulsive checking was measured. This dataset has the same Design and Procedure as dataset deposits for StudyID Q25 doi:10.20383/102.0439 and StudyID Q28 doi:10.20383/102.0436 https://creativecommons.org/licenses/by/4.0/
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Project_04 Q39 StudyTitle Probing for drugs that mitigate sensitization and compulsive checking: effect of mCPP dose (0 0.3125 0.625 and 1.25 mg/kg) on expression induced by a low dose of QNP (0.125 mg/kg)
Federated Research Data Repository / dépôt fédéré de données de recherche
Tucci, Mark C.; Szechtman, Henry; Dvorkin-Gheva, Anna — This study (Q39) is one of a series of studies performed in the Szechtman lab at McMaster University and deposited in the FRDR public repository as a collection under the name "A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection". This collection as a whole constitutes a big dataset containing raw data objects of video, track, and path plot records of rats exploring for 55 minutes a large testing environment in a standardized paradigm during chronic treatment with psychostimulant drugs; for details of this big dataset see, https://www.frdr-dfdr.ca/repo/collection/szechtmanlab. The historical context for study Q39 was Project_04 entitled: "Probing for drugs that mitigate sensitization and compulsive checking". Title of experiment in Q39 was "Effect of mCPP dose (0.3125 0.625 or 1.25 mg/kg) on the expression of sensitization and compulsive checking induced by QNP (0.125 mg/kg)". https://creativecommons.org/licenses/by/4.0/
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Project_02 Q45 StudyTitle Probing the neurochemistry of sensitization and compulsive checking: dopamine and serotonin systems
Federated Research Data Repository / dépôt fédéré de données de recherche
Szechtman, Henry; Dvorkin-Gheva, Anna — This study (Q45) is one of a series of studies performed in the Szechtman lab at McMaster University and deposited in the FRDR public repository as a collection under the name "A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection". This collection as a whole constitutes a big dataset containing raw data objects of video, track, and path plot records of rats exploring for 55 minutes a large testing environment in a standardized paradigm during chronic treatment with psychostimulant drugs; for details of this big dataset see, https://www.frdr-dfdr.ca/repo/collection/szechtmanlab. The historical context for study Q45 was Project_02 entitled: "Probing the neurochemistry of sensitization and compulsive checking". Title of experiment in Q45 was "Effect of a low dose of 8OHDPAT (0.0625) co-injected with a threshold dose of QNP (0.0625 mg/kg) on the development of sensitization and compulsive checking". https://creativecommons.org/licenses/by/4.0/
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Project_09 Q27 StudyTitle Probing the environmental modulation of sensitization and compulsive checking: effect of having a different environment for the development and the expression of behavior under QNP
Federated Research Data Repository / dépôt fédéré de données de recherche
Szechtman, Henry; Dvorkin-Gheva, Anna — This study (Q27) is one of a series of studies performed in the Szechtman lab at McMaster University and deposited in the FRDR public repository as a collection under the name "A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection". This collection as a whole constitutes a big dataset containing raw data objects of video, track, and path plot records of rats exploring for 55 minutes a large testing environment in a standardized paradigm during chronic treatment with psychostimulant drugs; for details of this big dataset see, https://www.frdr-dfdr.ca/repo/collection/szechtmanlab. The historical context for study Q27 was Project_09 entitled: "Probing the environmental modulation of sensitization and compulsive checking". Title of experiment in Q27 was "Effect of sensitization in activity chambers or in the home cage on performance of compulsive checking in the open field". https://creativecommons.org/licenses/by/4.0/
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Project_08 Q21 StudyTitle Probing the parameters of sensitization and compulsive checking: characteristics of behavioral measures during pathogenesis of compulsive behavior
Federated Research Data Repository / dépôt fédéré de données de recherche
Szechtman, Henry; Dvorkin-Gheva, Anna; Perreault, Melissa L. — This study (Q21) is one of a series of studies performed in the Szechtman lab at McMaster University and deposited in the FRDR public repository as a collection under the name "A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection". This collection as a whole constitutes a big dataset containing raw data objects of video, track, and path plot records of rats exploring for 55 minutes a large testing environment in a standardized paradigm during chronic treatment with psychostimulant drugs; for details of this big dataset see, https://www.frdr-dfdr.ca/repo/collection/szechtmanlab. The historical context for study Q21 was Project_08 entitled: "Probing the parameters of sensitization and compulsive checking". Title of experiment in Q21 was "Development and temporal organization of compulsive checking induced by repeated injections of QNP (0.5 mg/kg)". This experiment was embedded in a larger study, Project_09 entitled: "Probing the environmental modulation of sensitization and compulsive checking", where the title of the experiment was "Effect of separating pups from maternal nest for 15 or 180 min on postnatal days 2 to 15 on the development of compulsive checking induced by repeated injections of quinpirole in adult male rats". https://creativecommons.org/licenses/by/4.0/
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Project_04 Q38 StudyTitle Probing for drugs that mitigate sensitization and compulsive checking: effect of mCPP dose (0 0.625 and 1.25 mg/kg) on development produced by a medium dose of QNP (0.25 mg/kg)
Federated Research Data Repository / dépôt fédéré de données de recherche
Tucci, Mark C.; Szechtman, Henry; Dvorkin-Gheva, Anna — This study (Q38) is one of a series of studies performed in the Szechtman lab at McMaster University and deposited in the FRDR public repository as a collection under the name "A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection". This collection as a whole constitutes a big dataset containing raw data objects of video, track, and path plot records of rats exploring for 55 minutes a large testing environment in a standardized paradigm during chronic treatment with psychostimulant drugs; for details of this big dataset see, https://www.frdr-dfdr.ca/repo/collection/szechtmanlab. The historical context for study Q38 was Project_04 entitled: "Probing for drugs that mitigate sensitization and compulsive checking". Title of experiment in Q38 was "Effect of mCPP dose (0.625 and 1.25 mg/kg) co-injected with a fixed dose of QNP (0.25 mg/kg) on the development of sensitization and compulsive checking". https://creativecommons.org/licenses/by/4.0/
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Project_02 Q47 StudyTitle Probing the neurochemistry of sensitization and compulsive checking: dopamine and serotonin systems
Federated Research Data Repository / dépôt fédéré de données de recherche
Szechtman, Henry; Dvorkin-Gheva, Anna — This study (Q47) is one of a series of studies performed in the Szechtman lab at McMaster University and deposited in the FRDR public repository as a collection under the name "A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection". This collection as a whole constitutes a big dataset containing raw data objects of video, track, and path plot records of rats exploring for 55 minutes a large testing environment in a standardized paradigm during chronic treatment with psychostimulant drugs; for details of this big dataset see, https://www.frdr-dfdr.ca/repo/collection/szechtmanlab. The historical context for study Q47 was Project_02 entitled: "Probing the neurochemistry of sensitization and compulsive checking". Title of experiment in Q47 was "Effect of 8OHDPAT dose (0 0.03125 0.0625 0.125 mg/kg) co-injected with a low dose of QNP (0.125 mg/kg) on the development of sensitization and compulsive checking (batch 2). Q47 was a repeat of Study Q46 (hence "batch 2" in title of experiment for Q47). For Q47, like for Q46 (dataset doi: 10.20383/102.0419), each rat received 13 trials in the open field. However, in IDStudy Q47, rats received a 14th trial in the open field, but for this test the open field was emptied of the 4 objects normally in it. This particular trial is grouped under Project_09 ("Probing the environmental modulation of sensitization and compulsive checking"), giving IDStudy Q47 a second title, "Probing the environmental modulation of sensitization and compulsive checking: influence of no objects in the open field on expression". The historical context for IDStudy Q47 includes the introduction of "enriched" housing, that is, a piece of black plastic tube was placed in the rat's home cage (prior to this study, there were no objects in the home cage). A comparison of study Q47 with Q46 showed that "enriched" housing did not influence the development of sensitization or compulsive checking https://creativecommons.org/licenses/by/4.0/
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Project_02 Q34 StudyTitle Probing the neurochemistry of sensitization and compulsive checking: dopamine and serotonin systems
Federated Research Data Repository / dépôt fédéré de données de recherche
Alkhatib, Ahmad Hamdi; Szechtman, Henry; Dvorkin-Gheva, Anna — This study (Q34) is one of a series of studies performed in the Szechtman lab at McMaster University and deposited in the FRDR public repository as a collection under the name "A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection". This collection as a whole constitutes a big dataset containing raw data objects of video, track, and path plot records of rats exploring for 55 minutes a large testing environment in a standardized paradigm during chronic treatment with psychostimulant drugs; for details of this big dataset see, https://www.frdr-dfdr.ca/repo/collection/szechtmanlab. The historical context for study Q34 was Project_02 entitled: "Probing the neurochemistry of sensitization and compulsive checking". Title of the fist experiment in Q34 was "Comparison of the QNP (0.2 mg/kg) and the 8OHDPAT (1 mg/kg) effects on the development of sensitization and compulsive checking". Title of the second experiment in Q34 was "Effect of QNP+8OHDPAT co-treatment on the expression of sensitization and compulsive checking" Study Q34 was part also of a second project, Project_04 entitled: "Probing for drugs that mitigate sensitization and compulsive checking" where title of the experiment was "Effect of acute escitalopram on the expression of sensitization and compulsive checking". https://creativecommons.org/licenses/by/4.0/
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Project_02 Q23 StudyTitle Probing the neurochemistry of sensitization and compulsive checking: dopamine and kappa opioid systems
Federated Research Data Repository / dépôt fédéré de données de recherche
Szechtman, Henry; Dvorkin-Gheva, Anna; Perreault, Melissa L. — This study (Q23) is one of a series of studies performed in the Szechtman lab at McMaster University and deposited in the FRDR public repository as a collection under the name "A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection". This collection as a whole constitutes a big dataset containing raw data objects of video, track, and path plot records of rats exploring for 55 minutes a large testing environment in a standardized paradigm during chronic treatment with psychostimulant drugs; for details of this big dataset see, https://www.frdr-dfdr.ca/repo/collection/szechtmanlab. The historical context for study Q23 was Project_02 entitled: "Probing the neurochemistry of sensitization and compulsive checking". Title of experiment in Q23 was "Effect of co-treatment with kappa agonist U69593 and QNP on the development of sensitization and compulsive checking". https://creativecommons.org/licenses/by/4.0/
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Project_04 Q33 StudyTitle Probing for drugs that mitigate sensitization and compulsive checking: acute treatment with escitalopram or imipramine
Federated Research Data Repository / dépôt fédéré de données de recherche
Szechtman, Henry; Dvorkin-Gheva, Anna — This study (Q33) is one of a series of studies performed in the Szechtman lab at McMaster University and deposited in the FRDR public repository as a collection under the name "A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection". This collection as a whole constitutes a big dataset containing raw data objects of video, track, and path plot records of rats exploring for 55 minutes a large testing environment in a standardized paradigm during chronic treatment with psychostimulant drugs; for details of this big dataset see, https://www.frdr-dfdr.ca/repo/collection/szechtmanlab. The historical context for study Q33 was Project_04 entitled: "Probing for drugs that mitigate sensitization and compulsive checking". Title of the experiment in Q33 was "Effect of acute escitalopram or imipramine on the expression of compulsive checking". Study Q33 was part also of a second project, Project_02 entitled: "Probing the neurochemistry of sensitization and compulsive checking" where title of the experiment was "Effect of substitution of QNP with 8OHDPAT on the expression of sensitization and compulsive checking". https://creativecommons.org/licenses/by/4.0/
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Project_09 Q29 StudyTitle Probing the environmental modulation of sensitization and compulsive checking: influence of a small ledge around OF
Federated Research Data Repository / dépôt fédéré de données de recherche
Szechtman, Henry; Dvorkin-Gheva, Anna — This study (Q29) is one of a series of studies performed in the Szechtman lab at McMaster University and deposited in the FRDR public repository as a collection under the name "A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection". This collection as a whole constitutes a big dataset containing raw data objects of video, track, and path plot records of rats exploring for 55 minutes a large testing environment in a standardized paradigm during chronic treatment with psychostimulant drugs; for details of this big dataset see, https://www.frdr-dfdr.ca/repo/collection/szechtmanlab. The historical context for study Q29 was Project_09 entitled: "Probing the environmental modulation of sensitization and compulsive checking". Title of the experiment in Q29 was "Effect of a small ledge on open field on the development of sensitization and compulsive checking". Study Q29 was also part of a second project, Project_02 entitled: "Probing the neurochemistry of sensitization and compulsive checking", where title of the experiment was "Effect of CP809101 (5HT2C agonist) on the expression of sensitization and compulsive checking in an open field bordered by a low ledge". Note that Q29 dataset does not have the raw data object, path plot of routes of locomotion. https://creativecommons.org/licenses/by/4.0/
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Project_01 Q25 StudyTitle Probing the neural circuit mediating sensitization and compulsive checking: role of the basal lateral amygdala (BLA) on development, and, on expression
Federated Research Data Repository / dépôt fédéré de données de recherche
Bisnaire, Liane D.; Szechtman, Henry; Dvorkin-Gheva, Anna — This study (Q25) is one of a series of studies performed in the Szechtman lab at McMaster University and deposited in the FRDR public repository as a collection under the name "A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection". This collection as a whole constitutes a big dataset containing raw data objects of video, track, and path plot records of rats exploring for 55 minutes a large testing environment in a standardized paradigm during chronic treatment with psychostimulant drugs; for details of this big dataset see, https://www.frdr-dfdr.ca/repo/collection/szechtmanlab. The historical context for study Q25 was Project_01 entitled: "Probing the neural circuit mediating sensitization and compulsive checking". This project had two separate studies, designated as Q25Bla1 and Q25Bla2. The title of study Q25Bla1 was "Probing the neural circuit mediating sensitization and compulsive checking: role of the basal lateral amygdala (BLA) on development" and the title of study Q25Bla2 was "Probing the neural circuit mediating sensitization and compulsive checking: role of the basal lateral amygdala (BLA) on expression". Title of experiment in Q25Bla1 was "Effect of an NMDA lesion of the BLA on the development of sensitization and compulsive checking" and title of experiment in Q25Bla2 was "Effect of an NMDA lesion of the BLA on the expression of sensitization and compulsive checking". For the development study (Q25Bla1), rats received a lesion targeted at the BLA and the effect of this lesion on the induction of compulsive checking in our standard paradigm was measured. For the expression study (Q25Bla2), rats received our standard treatment to induce compulsive checking and then received a lesion targeted at the BLA and the effect of this lesion on the expression of compulsive checking was measured. This dataset has the same Design and Procedure as dataset deposits for StudyID Q26 doi:10.20383/102.0438 and StudyID Q28 doi:10.20383/102.0436 https://creativecommons.org/licenses/by/4.0/
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Project_12 Q42 StudyTitle Resynthesis of compulsive checking: NAc lesion plus mCPP (0.625 mg/kg) on injections 1-4
Federated Research Data Repository / dépôt fédéré de données de recherche
Tucci, Mark C.; Szechtman, Henry; Dvorkin-Gheva, Anna — This study (Q42) is one of a series of studies performed in the Szechtman lab at McMaster University and deposited in the FRDR public repository as a collection under the name "A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection". This collection as a whole constitutes a big dataset containing raw data objects of video, track, and path plot records of rats exploring for 55 minutes a large testing environment in a standardized paradigm during chronic treatment with psychostimulant drugs; for details of this big dataset see, https://www.frdr-dfdr.ca/repo/collection/szechtmanlab. The historical context for study Q42 was Project_12 entitled: "Resynthesis of compulsive checking". Title of experiment in Q42 was "Effect of NAc lesion plus mCPP (0.625 mg/kg on injections 1-4) in producing compulsive checking". https://creativecommons.org/licenses/by/4.0/

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(Source Repository: A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection (FRDR))

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